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针灸治疗哮喘:中医成果登上《Science》子刊封面

针灸治疗哮喘:中医成果登上《Science》子刊封面 上观新闻 原标题:中医成果登上《Science》子刊封面!上海中医药大学发现“针灸治疗哮喘”深层原理,有望制成抗哮喘新药 背部穴位入针,有效治疗哮喘,这一经典名方在分子细胞层面究竟有何机理? 北京时间2月8日下午,国际著名期刊《科学(Science)·转化医学》最新一期封面文章揭开谜底——前后历经约10年,上海中医药大学杨永清教授带领科研团队,在抗哮喘靶标和针灸效应物质的基础研究中取得重大进展。 他们不仅基于针灸临床率先发现全新的有效靶标 明确了体内一系列蛋白质反应 还找到能够模拟针刺效应的活性小分子 可转化为具有广阔应用前景的“针灸药” 《科学》主审编辑专门为论文成果做了评论 认为这是一篇令人振奋、引发深思的创新力作 解放日报·上观新闻了解到,这是中国中医人第一次在《科学》专业子刊发表拥有自主知识产权的原创性科学工作,也是中国科学家验证的第一个支气管哮喘新靶标。 《科学·转化医学》论文推介。 本次研究的突破点在哪里? 老中医针灸方子多年来改善支气管哮喘 支气管哮喘是常见呼吸道疾病,目前常规药物疗法主要是皮质激素、β2受体激动剂类药物,这些药物除了本身多种副作用之外,还很容易出现耐药乃至无法缓解症状等问题。甚至美国FDA曾质疑短效和长效β2受体激动剂,认为其可能引起病情加重、增加死亡率。 而中医界,以名老中医邵经明为代表的邵氏中医,70年来运用针刺大椎、风门、肺俞等穴位,显著改善哮喘患者呼吸功能,经验方子得以发展成熟。 杨永清团队验证“针灸改善哮喘”深层原理 但针刺是多靶向的,可激发上百种生化反应。其弟子杨永清教授领衔的研究团队,通过小鼠哮喘模型实验,“锁定”金属硫蛋白-2(MT-2),验证了其蛋白含量上调,对缓解哮喘发病起关键作用。 接着,他们又确认呼吸道中的“双蛋白”绑定关系:上游的MT-2在气管平滑肌细胞上还必须有下游的“作用受体”——肌动蛋白结合蛋白-2(Transgelin-2)。原来,针灸的物理刺激正是引发了这对蛋白的结合,从而舒张气管、平喘止咳。 研究还发现“潜在的抗哮喘新药”,还是针灸药 针灸人并未止步于此。论文第一作者、上海中医大和上海市针灸经络研究所尹磊淼博士告诉解放日报·上观新闻记者,中科院上海药物研究所所长蒋华良早在2003年就和杨永清团队成立“针灸中药效应联合实验室”,他们继续开展合作,利用分子对接、虚拟筛选等技术,将下游蛋白Transgelin-2作为“鱼饵”,从6000个候选化合物中,筛选出了可以特异性地与新靶标结合的分子化合物。 这个针锋相对的小分子,具有“类针刺”的舒张气管平滑肌作用,成为潜在的抗哮喘新药。因此,尹磊淼的“师爷”、杨永清的博导、上海市中医药研究院副院长陈汉平教授表示,新发现的活性小分子,探索出从中医临床到实验室再回到临床的转化医学模式,可谓一剂“针灸药”。上海药物所药物发现与设计中心主任、该文共同作者朱维良教授也认为,此项研究可以称得上中国第一个自主知识产权的靶标和新药发现。 为解决哮喘当前困境开辟了一条新的路径 “正如《科学》杂志评审所言,靶向Transgelin-2受体的治疗为解决哮喘当前困境开辟了一条新的路径。”上海中医大科技实验中心副主任、市针灸所课题负责人王宇,向解放日报·上观新闻记者表示,这一从中医而来的新药发现与开发策略,也是应用当代生物技术阐释中国传统针灸学机制的成功尝试,对保持我国在针灸研究领域的国际领先地位,率先在这一领域取得原创性的自主知识产权具有重要战略意义。事实上,针灸与针灸药并非谁替代谁,而是互为补充,多种理化手段,综合施药用针。...
Get a winter tune-up with acupuncture and Chinese medicine

Get a winter tune-up with acupuncture and Chinese medicine

  Yoga, Yoga Everywhere There are over 40 different styles of yoga taught in the United States. All of the types of yoga overlap and have a common goal – the union of mind, body and spirit. Each style of yoga is distinguished by particular practices. Some types of yoga are quite physical, building strength and flexibility, while others are restorative and meditative. Below is a short list of a few styles of yoga. Which one is right for you? Ashtanga yoga – Developed in 1937 by Sri K. Pattabhi Jois. This style of yoga focuses upon building strength and heat in the body. It provides a fast-paced, and sometimes intense, workout through a series of challenging poses that are taught in a sequential order. Bikram yoga – Be prepared to sweat. Bikram is performed in a room heated to about 100 degrees. This yoga consists of 26 poses that are repeated twice in the same order. The intense workout warms the body and muscles and increases flexibility. Bring plenty of water, a towel and possibly a change of clothes. Iyengar Yoga – B.K.S. Iyengar developed this style of yoga in 1937. It is focused upon the correct alignment of the body in all poses which may be held for up to five minutes or more, in order to correct alignment and posture. Iyengar will build, strength, endurance and flexibility. The classes may also use props, such as, straps, blocks and blankets to get the body into the perfect pose. Kundalini yoga – This ancient style of yoga has been practiced in India for centuries. It came to the...
6 best Chinese herbs to lower cholesterol

6 best Chinese herbs to lower cholesterol

List here are the 6 best Chinese herbs to lower cholesterol   Hawthorn Hawthorn contains hawthorn acid, tartaric acid, citric acid and other substances. It can dilate blood vessels, lower blood pressure, lower cholesterol, and increase gastric digestive enzymes. Hawthorn is available as tablets, granules. it is also available in dried raw fruit for herbal tea or decoction.   Polygonum multiflorum Polygonum multiflorum can promote intestinal peristalsis, reduce cholesterol absorption and accelerate the excretion of cholesterol. Hence reduce cholesterol. It has anti-atherosclerosis effect. Clinical you can used Polygonum multiflorum tablets or granules 2.5 gram each dosage, 3 times per day. Polygonum multiflorumthe also helps constipation, particularly suits for elderly patient who has chronic constipation and can be diagnosed as Liver and Kidney deficiency in Chinese medicine.   Rhubarb root Rhubarb root can lower blood pressure and cholesterol. Clinical Rhubarb can be ingested as 0.25 gram per dosage, 4 times a day. Triglycerides may reduce after one month treatment. As Rhubard has a strong laxative effect, it is particularly suitable for patients with high cholesterol and constipation.   Cassia seed Cassia seed inhibits serum cholesterol and atherosclerosis plaque formation. Take fried Cassia as herbal tea can gradually lower cholesterol levels close to normal range. Average dosage is 5 to 10 gram per day, for a whole month.   Pollen Typhae Pollen Typhae inhibits intestinal absorption of exogenous cholesterol. Therefore it can reduce lipids in the blood. Note only raw Pollen Typhae is effective in reduce cholesterol (charcoaled Typhae is widely used for excessive menstruation and painful menstruation).   Ginkgo biloba Research discovered that Ginkgo biloba has coronary dilation effect and it is able to lower serum cholesterol. Ginkgo biloba can...

Quit Smoking Tips

Quit Smoking Tips   Below, I have listed a few quit smoking tips or techniques that have been proven effective in helping to combat your cravings. As long as you employ one or more of these concepts, you take another step toward a healthier and happier smoke-free you! First step: when and where are your cravings? The first step toward becoming “smoke free” is to identify when and where your smoking cravings occur, i.e. after eating, after a cup of coffee, during stressful situations, etc. When you become aware of the triggers that precede your cravings, it will become easier for you to begin to break the habit. As long as you refrain from grabbing a cigarette for at least 20-30 minutes after the craving trigger, you will have a much better chance of quitting. As time ticks by, it will become easier to remove yourself from the cravings and you may even forget you wanted a cigarette in the first place. Manage you habit Cravings may feel like they last forever, but will most likely dissipate within 3-5 minutes. Invent your own ideas to bust the cravings or use the suggestions below to help you manage them when they occur. Plan ahead by writing down these suggestions in your day planner, on post it notes in your house, car, or at your desk, or even on your screen saver. Remember to make these healing activities fun and enjoyable, as well as easily accessible! Affirmation An affirmation is positive statement, which when spoken repeatedly, helps to bolster the positive and desired changes you are embarking upon. Repeating the affirmation...

Stress

Getting cross, irritable and snap at people when you don’t really mean to? Frustrated and depressed? Feel your life is out of control? Push yourself too hard and beyond your tolerance level? You are suffering stress! Main causes of stress include: Occupational stress: Shouldering a heavy workload; reaching the expectations others set for you; constantly having to perform the job.Conflict with colleague or costumers. Emotional stress: The breakdown of a relationship; the loss of loved one (such as death of a spouse or truly loved one), divorce or marital separation. Physical stress: Taking on extra work; heavy training sessions The consequence of stress can be: Hormonal imbalance:pre-menstrual syndromes; Low blood sugar: result from poor diet or inadequate exercise. possible stress-related digestive disorders; Poor immune function: Caused by poor diet and lifestyle. Recurring allergies such as hayfever and food sensitivities; Possibly result in chronic infection; Anxiety or panic attack; Insomnia; Hypertension or High Cholesterol; Aging. How does acupuncture help relieve stress? Acupuncture help stimulate the body to “heal itself”. For all stress related symptoms acupuncture is a safe and very effective management method. Acupuncture treatment can help reduce the Stress Hormone, restore and natural balance of the physical, emotional and mental functions. Generally during and after acupuncture treatment you would feel much calmer, more relaxed and aware the improvement of your well-being. Many researches found that acupuncture can help release Endorphin which is a “Happy Hormones” making people feel relaxed and calm. How many sessions do I need acupuncture for stress? Most likely you will experience a great feeling from the very first treatment. However acupuncture gives increasing benefits with each treatment....

How to Boost Energy with Acupuncture in Winter

Boost Energy with Acupuncture in winter By: Diane Joswick, L.Ac., MSOM Recharge Your Battery this Winter with Acupuncture If you feel tired and drained, you are not alone. “Lack of energy” is one of the top five complaints that doctors hear in their offices. According to Oriental medicine, the cold months of winter are the perfect time to recharge your battery and generate vital energy – Qi – in order to live, look, and feel your best. The ancient Chinese believed that human beings should live in harmony with the natural cycles of their environment. The cold and darkness of winter urges us to slow down. This is the time of year to reflect on health, replenish energy and conserve strength. Winter is ruled by the Water element, which is associated with the Kidneys, Bladder and Adrenal Glands. The Kidneys are considered the source of all energy or “Qi” within the body. They store all of the reserve Qi in the body so that it can be used in times of stress and change, or to heal, prevent illness, and age gracefully. During the winter months, it is important to nurture and nourish our Kidney Qi; it is the time where this energy can be most easily depleted. Our bodies are instinctively expressing the fundamental principles of winter – rest, reflection, conservation and storage. The Nei Ching, an ancient Chinese classic, advises people to go to sleep early and rise late, after the sun’s rays have warmed the atmosphere a bit. This preserves your own Yang Qi for the task of warming in the face of cold. Eating warm...