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Innovative Clinical Trial Offers Hope

Australians diagnosed with Glioblastoma Multiforme (GBM), the most common and deadliest form of brain cancer, can now look forward to new treatment possibilities and improved chances of survival. The Australian Brain Cancer Mission, in collaboration with the Minderoo Foundation and the Cure Brain Cancer Foundation (CBCF), has announced an innovative clinical trial, GBM Adaptive Global Innovative Learning Environment (GBM AGILE), which aims to revolutionize the way GBM is treated.

A Grim Reality

Brain cancer has been a relentless adversary, with GBM accounting for a substantial portion of malignant brain tumors, contributing to the grim statistic that less than a quarter of those diagnosed are expected to live beyond five years. In 2020, 2,000 Australians were diagnosed with brain cancer, and these statistics underscore the urgent need for innovative approaches to treatment.

Mission for a Brighter Future

The Australian Brain Cancer Mission, supported by the Morrison Government’s Medical Research Future Fund and philanthropic contributions, seeks to reverse these statistics. It aspires to double survival rates and enhance the quality of life for brain cancer patients. The introduction of the GBM AGILE trial in Australia is a significant step towards achieving these goals.

GBM AGILE – Revolutionising Treatment

GBM AGILE is a versatile and adaptive trial approach with multiple “treatment arms,” offering the potential to expedite the clinical research process for GBM. This trial will enable researchers to simultaneously assess the effects of various unique drugs, revolutionizing the way treatments are developed and tailored to individual patients. GBM AGILE introduces a technique called adaptive randomization, which connects patients with therapies that have the greatest potential to treat their specific cancer, ensuring that effective treatments are identified more rapidly.

Collaborative Efforts for Success

The initiative has received support from various key players, including the Commonwealth Department of Health, Cancer Australia, the Minderoo Foundation, and the CBCF, which are working collaboratively to ensure its success. Bringing the GBM AGILE trial to Australia is a crucial step towards finding a cure for one of the most common and deadly forms of brain cancer. The Cure Brain Cancer Foundation CEO, Lance Kawaguchi, highlighted that the trial would provide innovative treatments and world-leading research to Australian patients.

Personalised Cancer Care

“GBM AGILE will bring world-leading research and innovative treatments to Australian patients. Cure Brain Cancer Foundation is proud to collaborate with the Government and Minderoo on this important initiative,” said Mr. Kawaguchi. This cutting-edge trial is designed to offer multiple treatment options to patients quickly, advancing a more personalized approach to cancer care, which represents the future of oncology.

Advancing the Future of Cancer Care

Dr. Steve Burnell, CEO of Minderoo Foundation’s Collaborate Against Cancer initiative, emphasized that providing new options to brain cancer patients is a priority. Adaptive platform trials, such as GBM AGILE, play a vital role in offering multiple treatment choices, driving more personalized approaches to cancer care, which is considered the future of cancer treatment.

Funding the Future

The GBM AGILE trial is a remarkable opportunity for Australians living with GBM. It promises to accelerate the development of effective treatments and ultimately improve the outlook for those diagnosed with this devastating disease. With up to $12 million available over four years from 2021-22, this initiative is a significant step forward in the fight against brain cancer.

A Beacon of Hope

The grant opportunity for researchers to undertake the GBM AGILE trial has been opened, and it represents a glimmer of hope for patients and their families. With ongoing support and collaboration between government entities, philanthropic organizations, and the scientific community, the fight against brain cancer is gaining momentum, and a brighter future for those affected by GBM is on the horizon. For more information on the grant round, visit: www.grants.gov.au

In the battle against brain cancer, GBM AGILE represents a beacon of hope, offering a promising pathway towards more effective treatments and, ultimately, a cure for this devastating disease.

Department of Health and Aged Care Media Release:


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