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Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on Micro environment of Ova in Patients with Endometriosis

Effect of Quyu Jiedu Granule (祛瘀解毒颗粒) on Micro environment of Ova in Patients with Endometriosis Lian Fang et al, Zhong Xi Yi He Xue Bao 2009 Feb;15(1):42-46 Chinese Journal of Integrated Medicine A chinese herb formula for endometriosis was given to women with  long term infertility and endometriosis before and during an IVF cycle and various ovarian parameters were compared with a group of women with endometriosis who embarked on IVF directly without taking the herbs. The group who took the herbs produced more eggs and had a higher fertilisation rate (although a difference in pregnancy rate was not reported). Additionally the follicles of the women who took the herbs showed a reduced level of inflammatory cytokines compared to the women in the control group.     Abstract Objective: To observe the effect of Quyu Jiedu Granules (QJG) on the microenvironment of ova in patients with endometriosis (EM). Methods: Twenty EM patients who received in vitro fertilization and embryo transfer (IVF-ET) were randomized equally into a treated group and a control group. Further, 20 patients who received IVF-ET due to oviduct factors were enrolled into a non-endometriosis group. The dosage of gonadotrophic hormone used, the number of ova attained, fertilization rate and clinical pregnancy rate were all observed, and the levels of tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) in follicular fluid as well as their mRNA expressions in ovarian granular cells were detected by RT-PCR on the very day of ovum attainment. Results: The ova attainment (13.80±6.87) and fertilization rate (0.69±0.31) in the treated group were all higher than the corresponding values in the control group (9.80±5.32 and 0.47±0.22); the...

Clinical Observations on the Treatment of Endometriosis by Combined Acupuncture and Herbs

Clinical Observations on the Treatment of Endometriosis by Combined Acupuncture and Herbs Fu Yu and Xia Tian, Shanghai Jnl Acup Moxa, 2005, Vol 3 Shanghai Journal of Acupuncture and Moxibustion This is just one trial of many carried out in China which looks at the clinical effectiveness of treatment of endometriosis with acupuncture and Chinese herbs. The investigators report that symptoms  and signs of the disease are treated effectively without side effects.   Abstract Objective: To compare the clinical efficacy of combined acupuncture and herbs with danazol for treatment of endometriosis. Methods: Seventy-eight patients were randomly divided into a combined acupuncture and herbs treatment group (40 cases) and a Westerm medicine control group (38 cases). Observation was made of changes in clinical symptoms, signs, serum CA 125, β-EP, PGE 2 and PGF 2α, and adverse reaction to the medicine in the two group. Results: The overall efficacy was similar in the two groups, but the effects on lumbosacral pain, anal downbearing distention, irregular menstruation and infertility were significantly better in the treatment group than in the control group(P < 0.05), and in the treatment group serum CA 125, PGE 2 and PGF 2α were significantly lower and serum β-EP was significanly higher after treatment than before (P < 0.05). Conclusion: Combined use of acupuncture and herbs has a marked effect on endometriosis and the adverse reaction is lower than the control...

Acupuncture Combined with Herbal Medicine Effects on Outcomes of Patients with Endometriosis Who Accepted IVF-ET

Acupuncture Combined with Herbal Medicine Effects on Outcomes of Patients with Endometriosis Who Accepted IVF-ET Yu Xiao-Li et al, Liaoning Journal of Traditional Chinese Medicine 2010 Vol 4 Liaoning Journal of Traditional Chinese Medicine This clinical trial carried out in north east China, recruited 180 women diagnosed with endometriosis who were doing a long down regulated IVF protocol. The women who were given acupuncture and chinese herbal medicine achieved significantly higher pregnancy rates than those in the other groups who did not have acupuncture. Abstract (English version) Objective: We investigated the effect of the intervention of acupuncture combined with herbal medicine on outcomes of patients with endometriosis (EM) who accepted in vitro fertilization-embryo transfer (IVF-ET). Methods: 180 cases from patients who took IVF-ET were randomly assigned into three groups,the control group(60 cases),the medicine group(60 cases),and the acupuncture combined with medicine group(60 cases).All the three groups were introduced with gonadotropin releasing hormone agonist(GnRH a) long protocol,and the curative effects were compared between groups. Results: The total effective rate, number of retrieved oocytes, rate of fertilization, implantation rate, and pregnant rate in the acupuncture combined with medicine group were all higher than those in the medicine group, which there were significant statistical differences(P0.05). The scores of the patients who accepted treatment in the two groups had significant difference (P0.05). Conclusion: Treatment of acupuncture combined with herbal medicine has remarkable effect on the patients who took IVF for ET, which is better than the medicine...