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针灸治疗哮喘:中医成果登上《Science》子刊封面

上观新闻

原标题:中医成果登上《Science》子刊封面!上海中医药大学发现“针灸治疗哮喘”深层原理,有望制成抗哮喘新药背部穴位入针,有效治疗哮喘,这一经典名方在分子细胞层面究竟有何机理?

北京时间2月8日下午,国际著名期刊《科学(Science)·转化医学》最新一期封面文章揭开谜底——前后历经约10年,上海中医药大学杨永清教授带领科研团队,在抗哮喘靶标和针灸效应物质的基础研究中取得重大进展。

他们不仅基于针灸临床率先发现全新的有效靶标

明确了体内一系列蛋白质反应

还找到能够模拟针刺效应的活性小分子

可转化为具有广阔应用前景的“针灸药”

《科学》主审编辑专门为论文成果做了评论

认为这是一篇令人振奋、引发深思的创新力作

解放日报·上观新闻了解到,这是中国中医人第一次在《科学》专业子刊发表拥有自主知识产权的原创性科学工作,也是中国科学家验证的第一个支气管哮喘新靶标。

《科学·转化医学》论文推介。

 

本次研究的突破点在哪里?

老中医针灸方子多年来改善支气管哮喘

支气管哮喘是常见呼吸道疾病,目前常规药物疗法主要是皮质激素、β2受体激动剂类药物,这些药物除了本身多种副作用之外,还很容易出现耐药乃至无法缓解症状等问题。甚至美国FDA曾质疑短效和长效β2受体激动剂,认为其可能引起病情加重、增加死亡率。

而中医界,以名老中医邵经明为代表的邵氏中医,70年来运用针刺大椎、风门、肺俞等穴位,显著改善哮喘患者呼吸功能,经验方子得以发展成熟。

 

杨永清团队验证“针灸改善哮喘”深层原理

但针刺是多靶向的,可激发上百种生化反应。其弟子杨永清教授领衔的研究团队,通过小鼠哮喘模型实验,“锁定”金属硫蛋白-2(MT-2),验证了其蛋白含量上调,对缓解哮喘发病起关键作用。

接着,他们又确认呼吸道中的“双蛋白”绑定关系:上游的MT-2在气管平滑肌细胞上还必须有下游的“作用受体”——肌动蛋白结合蛋白-2(Transgelin-2)。原来,针灸的物理刺激正是引发了这对蛋白的结合,从而舒张气管、平喘止咳。

 

研究还发现“潜在的抗哮喘新药”,还是针灸药

针灸人并未止步于此。论文第一作者、上海中医大和上海市针灸经络研究所尹磊淼博士告诉解放日报·上观新闻记者,中科院上海药物研究所所长蒋华良早在2003年就和杨永清团队成立“针灸中药效应联合实验室”,他们继续开展合作,利用分子对接、虚拟筛选等技术,将下游蛋白Transgelin-2作为“鱼饵”,从6000个候选化合物中,筛选出了可以特异性地与新靶标结合的分子化合物。

这个针锋相对的小分子,具有“类针刺”的舒张气管平滑肌作用,成为潜在的抗哮喘新药。因此,尹磊淼的“师爷”、杨永清的博导、上海市中医药研究院副院长陈汉平教授表示,新发现的活性小分子,探索出从中医临床到实验室再回到临床的转化医学模式,可谓一剂“针灸药”。上海药物所药物发现与设计中心主任、该文共同作者朱维良教授也认为,此项研究可以称得上中国第一个自主知识产权的靶标和新药发现。

 

为解决哮喘当前困境开辟了一条新的路径

“正如《科学》杂志评审所言,靶向Transgelin-2受体的治疗为解决哮喘当前困境开辟了一条新的路径。”上海中医大科技实验中心副主任、市针灸所课题负责人王宇,向解放日报·上观新闻记者表示,这一从中医而来的新药发现与开发策略,也是应用当代生物技术阐释中国传统针灸学机制的成功尝试,对保持我国在针灸研究领域的国际领先地位,率先在这一领域取得原创性的自主知识产权具有重要战略意义。事实上,针灸与针灸药并非谁替代谁,而是互为补充,多种理化手段,综合施药用针。

杨永清教授带领科研团队。

Get a winter tune-up with acupuncture and Chinese medicine

Yoga, Yoga Everywhere

There are over 40 different styles of yoga taught in the United States. All of the types of yoga overlap and have a common goal – the union of mind, body and spirit. Each style of yoga is distinguished by particular practices.
Some types of yoga are quite physical, building strength and flexibility, while others are restorative and meditative. Below is a short list of a few styles of yoga.

 

Which one is right for you?

 

Ashtanga yoga – Developed in 1937 by Sri K. Pattabhi Jois. This style of yoga focuses upon building strength and heat in the body. It provides a fast-paced, and sometimes intense, workout through a series of challenging poses that are taught in a sequential order.

 

Bikram yoga – Be prepared to sweat. Bikram is performed in a room heated to about 100 degrees. This yoga consists of 26 poses that are repeated twice in the same order. The intense workout warms the body and muscles and increases flexibility. Bring plenty of water, a towel and possibly a change of clothes.

 

Iyengar Yoga – B.K.S. Iyengar developed this style of yoga in 1937. It is focused upon the correct alignment of the body in all poses which may be held for up to five minutes or more, in order to correct alignment and posture. Iyengar will build, strength, endurance and flexibility. The classes may also use props, such as, straps, blocks and blankets to get the body into the perfect pose.

 

Kundalini yoga – This ancient style of yoga has been practiced in India for centuries. It came to the United States in 1969 by Yogi Bhajan. Kundalini yoga incorporates breathing exercises, chanting, meditation and yoga poses designed to stimulate the nervous system and meridian organ systems in order to free up blocked energy.
Acu yoga – Acu-Yoga is a practical yoga method that can release blocked Qi energy by applying acupressure to specific points upon the body. Acu-Yoga increases the circulation of Qi flowing throughout the body in order to balance and strengthen overall health. This style of yoga incorporates yoga poses, breathing techniques, meditation and acupressure.

 

Winter Health Foods

During the winter it is healthy to cook with “warming foods.” The weather is cooler, and your body needs to generate extra warmth in order to keep it functioning optimally.

Winter foods usually require a bit more preparation. These foods should be cooked longer and slower so they can provide you with meals that will keep you warmer. This is the time of year to stoke your inner fire, avoid raw foods, like salads and cold drinks, as these will cool your digestive function.

The winter diet should be made up of complex carbohydrates from whole grains, squash and root veggies, such as carrots, beets, turnips, potatoes, onions and garlic.

Thick and hearty soups and stews are especially good this time of year. They are nutritious, warming, easy to digest, and your home will smell wonderfully inviting.

Spice up your meals with a little ginger, a dash of cayenne, or garlic. These will add heat to your meals and warmth down to your toes

 

Stay in tip-top shape!

Here are a few easy pointers on how you can support and promote your own health this time of year:

 

Sleep.

Early to bed, early to rise, makes a person healthy, wealthy and wise. Go to bed early and if possible, wake up after the sun appears in the morning. Extra sleep will also benefit you if feel as though you are coming down with something. If you do become ill, naps may help you recover faster.

 

“C” it.

Load up on Vitamin C and other multivitamins. These can help support your health.

Surround yourself with friends and family. If you can gather around a fire, all the merrier.

 

Water, water everywhere.

Drink water. Every cell of your body requires this liquid gold to keep it lubricated and running smoothly.
Avoid the consumption of ice cream and iced beverages. If possible, drink liquids at room temperature. Too many colds foods, especially during the colder months, can disrupt your digestion.

 

Stress.

Try to avoid it as much as possible. If you can’t, adopt habits that will enable you to de-stress, such as meditation, yoga, dance, reading, acupuncture, or painting.

 

Exercise.

You have heard it a thousand times, exercise, exercise, exercise. There is no substitute for the health-promoting benefits of this easy task. Get up to 20 minutes of heart pumping exercise daily.

 

Take Chinese herbs that support the immune function.

Astragalus, Osha root, Reishi and Shitake mushrooms are helpful. These have been used for thousands of years by Chinese herbalists to keep people healthy and strong.

 

Come in for acupuncture treatments.

Chinese medicine and acupuncture works extremely well when you have a cold, and also as a tune up to stimulate the healing capacity of your body. If you begin to get the sniffles, body chills, or feel under the weather, give us a call, we may be able to help!

6 best Chinese herbs to lower cholesterol

List here are the 6 best Chinese herbs to lower cholesterol

Hawthorn

Hawthorn

Hawthorn

Hawthorn contains hawthorn acid, tartaric acid, citric acid and other substances. It can dilate blood vessels, lower blood pressure, lower cholesterol, and increase gastric digestive enzymes. Hawthorn is available as tablets, granules. it is also available in dried raw fruit for herbal tea or decoction.

 

Polygonum multiflorum

Polygonum multiflorum Thunb

Polygonum multiflorum Thunb

Polygonum multiflorum can promote intestinal peristalsis, reduce cholesterol absorption and accelerate the excretion of cholesterol. Hence reduce cholesterol. It has anti-atherosclerosis effect.

Clinical you can used Polygonum multiflorum tablets or granules 2.5 gram each dosage, 3 times per day.

Polygonum multiflorumthe also helps constipation, particularly suits for elderly patient who has chronic constipation and can be diagnosed as Liver and Kidney deficiency in Chinese medicine.

 

Rhubarb root

Rhubarb Dahuang

Rhubarb Dahuang

Rhubarb root can lower blood pressure and cholesterol.

Clinical Rhubarb can be ingested as 0.25 gram per dosage, 4 times a day. Triglycerides may reduce after one month treatment.

As Rhubard has a strong laxative effect, it is particularly suitable for patients with high cholesterol and constipation.

 

Cassia seed

Cassia Seed

Cassia Seed

Cassia seed inhibits serum cholesterol and atherosclerosis plaque formation. Take fried Cassia as herbal tea can gradually lower cholesterol levels close to normal range. Average dosage is 5 to 10 gram per day, for a whole month.

 

Pollen Typhae

Pollen Typhae

Pollen Typhae

Pollen Typhae inhibits intestinal absorption of exogenous cholesterol. Therefore it can reduce lipids in the blood. Note only raw Pollen Typhae is effective in reduce cholesterol (charcoaled Typhae is widely used for excessive menstruation and painful menstruation).

 

Ginkgo biloba

Ginkgo biloba

Ginkgo biloba

Research discovered that Ginkgo biloba has coronary dilation effect and it is able to lower serum cholesterol. Ginkgo biloba can be purchased from health food shop as tablets. At Almond Wellness Centre we have granule form.

Quit Smoking Tips

Quit Smoking Tips

Below, I have listed a few quit smoking tips or techniques that have been proven effective in helping to combat your cravings. As long as you employ one or more of these concepts, you take another step toward a healthier and happier smoke-free you!

 

Quit smoking 2015First step: when and where are your cravings?

The first step toward becoming “smoke free” is to identify when and where your smoking cravings occur, i.e. after eating, after a cup of coffee, during stressful situations, etc.

When you become aware of the triggers that precede your cravings, it will become easier for you to begin to break the habit. As long as you refrain from grabbing a cigarette for at least 20-30 minutes after the craving trigger, you will have a much better chance of quitting. As time ticks by, it will become easier to remove yourself from the cravings and you may even forget you wanted a cigarette in the first place.

 

Manage you habit

Cravings may feel like they last forever, but will most likely dissipate within 3-5 minutes. Invent your own ideas to bust the cravings or use the suggestions below to help you manage them when they occur. Plan ahead by writing down these suggestions in your day planner, on post it notes in your house, car, or at your desk, or even on your screen saver. Remember to make these healing activities fun and enjoyable, as well as easily accessible!

 

Affirmation

An affirmation is positive statement, which when spoken repeatedly, helps to bolster the positive and desired changes you are embarking upon. Repeating the affirmation helps to remind you of why you are no longer smoking, imprinting in your mind and body a positive image of a “smoke –free” existence.

 

An example of an affirmation might be:

“I am a non-smoker, and I make healthy choices in my life”, or

“I am strong, healthy, and vibrant, and choose healthy things in my life.”

 

Setting boundaries

Set up contracts with other smokers that you associate with. Let them know that you are choosing to kick the habit and that you want them to refrain from smoking around you. This includes friends, spouses, and family members.

If you are in a public location and someone lights a cigarette, you can do one of two things:

  • ask them to put it out, or
  • leave the situation and socialise elsewhere.

The desire to pick up a cigarette and smoke, when others are doing so, is strong.

MAKE SUER YOU TAKE CARE OF YOURSELF.

 

Do what is right to support your “smoke-free” journey.

 

Support person

The decision to quit smoking is an important one, and by taking the positive steps toward quitting, you may experience some unpleasant and uncomfortable emotions. Ask someone, whom you are close with, to act as sounding board for you, and to provide you with encouragement.

Stop Smoking Program

Ear seeds/needles

In your acupuncture treatment, you may receive ear seeds/needles. These seeds/needles are held in place on the ear with a small piece of adhesive tape, and are located on specific points in your ear which help reduce anxiety and stress, calm the mind, cleanse the lungs, open the chest, reduce the appetite, and strengthen will power. When a craving occurs, rub each of the ear seeds for approximately 15-30 seconds. Rubbing them throughout the day will help fortify and support your acupuncture treatments.

 

Chinese herbal tea

Chinese herbal tea can help detox and ease off the discomfort around your mouth, nose and chest area. It also has calm effect, which can help fight cravings.

 

Breathe deeply

Many of us do not take full, deep breaths. Take time out during the day to breathe deeply. Begin by inhaling into your belly. Then, allow the breath to move up into your chest, making it rise as full as you can. As you exhale, focus on completely expelling the air from your body. In you exhale, making the sound SSSSSSSSSSSS, activates and opens the lungs and chest.

 

Refrain from drinking coffee

Coffee can dehydrate your body and lead to cravings. Most people associate a cup of coffee with a cigarette. In order to be successful, you need to break the coffee and cigarette relationship.

 

Drink Water

Sip water frequently throughout the day. It will help to curb your cravings and will cleanse and flush the body tissues.

 

Food choices

Eat lots of carrots, celery and other vegetables. They will satiate your appetites, as well as provide your body with the nutrients it needs to regain health and vitality. Candy and other sweets will upset the sugar level in your body, which can aggravate any withdrawal symptoms that you may experience. Sugar substitutes, such as NutraSweet, are sweeter than sugar and can cause even more cravings.

 

Laser quit smoking program at Almond Wellness Centre

How to Boost Energy with Acupuncture in Winter

Boost Energy with Acupuncture in winter

By: Diane Joswick, L.Ac., MSOM

 

Recharge Your Battery this Winter with Acupuncture

If you feel tired and drained, you are not alone. “Lack of energy” is one of the top five complaints that doctors hear in their offices. According to Oriental medicine, the cold months of winter are the perfect time to recharge your battery and generate vital energy – Qi – in order to live, look, and feel your best.

The ancient Chinese believed that human beings should live in harmony with the natural cycles of their environment. The cold and darkness of winter urges us to slow down. This is the time of year to reflect on health, replenish energy and conserve strength.

Winter is ruled by the Water element, which is associated with the Kidneys, Bladder and Adrenal Glands. The Kidneys are considered the source of all energy or “Qi” within the body. They store all of the reserve Qi in the body so that it can be used in times of stress and change, or to heal, prevent illness, and age gracefully.

During the winter months, it is important to nurture and nourish our Kidney Qi; it is the time where this energy can be most easily depleted. Our bodies are instinctively expressing the fundamental principles of winter – rest, reflection, conservation and storage.

The Nei Ching, an ancient Chinese classic, advises people to go to sleep early and rise late, after the sun’s rays have warmed the atmosphere a bit. This preserves your own Yang Qi for the task of warming in the face of cold.

Eating warm hearty soups, whole grains, and roasted nuts help to warm the body’s core and to keep us nourished. Sleep early, rest well, stay warm, and expend a minimum quantity of energy.

Seasonal acupuncture treatments in winter serve to nurture and nourish kidney Qi which can greatly enhance the body’s ability to thrive in times of stress, aid in healing, prevent illness and increase vitality.

Here are some dietary suggestions that can lead to an increase in vitality and radiant health

  • Water – The Kidneys are associated with the Water element. Drink ample water, at room temperature, throughout the day.
  • Kidney Shaped Foods – Black beans and kidney beans are excellent examples of kidney shaped foods that nourish and benefit Kidney Qi.
  • Blue and Black Foods – The colors blue and black correspond to the Water element of the Kidneys and are thought to strengthen the Water element. Include blueberries, blackberries, mulberry and black beans in your diet.
  • Seeds – Flax, pumpkin, sunflower and black sesame seeds relate to fertility and growth which is governed by Kidney Qi.
  • Nuts – Walnuts and chestnuts have been found to be especially effective for increasing Kidney Qi.
  • Vegetables – Dark, leafy green vegetables are the best choice for Kidney Qi.
  • Other Kidney Qi boosting veggies include asparagus, cucumbers and celery.